Future Medicinal Chemistry文献大全第5页

Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights.
abstract：:This perspective explores the origins of both fluorine and medicinal chemistry a century ago and traces the early history of the intersection of these areas and the subsequent roles that fluorine has played in advancing medicinal innovations and diagnoses during the past 60 years. The overview highlights remarkable br...

journal_title：Future medicinal chemistry

pub_type： 杂志文章

doi：10.4155/fmc.09.65

authors： Filler R,Saha R

更新日期：2009-08-01 00:00:00
New preparation and synthetic reactions of 3,3,3-trifluoropropynyllithium, -borate and -stannane: facile synthesis of trifluoromethylated allenes, arylacetylenes and enynes.
abstract：BACKGROUND:Since trifluoromethyl-containing compounds have found diverse applications in the fields of pharmaceuticals and agrochemicals, facile and selective synthetic methods for trifluoromethyl-substituted compounds are an essential tool for advanced medicinal chemistry. Now that diverse synthetic transformations of...

journal_title：Future medicinal chemistry

pub_type： 杂志文章

doi：10.4155/fmc.09.69

authors： Shimizu M,Higashi M,Takeda Y,Murai M,Jiang G,Asai Y,Nakao Y,Shirakawa E,Hiyama T

更新日期：2009-08-01 00:00:00
Current and future perspectives on the chemotherapy of the parasitic protozoa Trichomonas vaginalis and Entamoeba histolytica.
abstract：:Trichomonas vaginalis and Entamoeba histolytica are clinically important protozoa that affect humans. T. vaginalis produces sexually transmitted infections and E. histolytica is the causative agent of amebic dysentery. Metronidazole, a compound first used to treat T. vaginalis in 1959, is still the main drug used worl...

journal_title：Future medicinal chemistry

pub_type： 杂志文章,评审

doi：10.4155/fmc.09.59

authors： Moya IA,Su Z,Honek JF

更新日期：2009-07-01 00:00:00
Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium's success?
abstract：:This review aims to bring the reader up to date with the more recent ruthenium compounds that have been synthesized and tested for their cytotoxicity. The chemistry of these transition metal complexes will be introduced and the basic principles that govern their common behavior outlined. The recent history of establis...

journal_title：Future medicinal chemistry

pub_type： 杂志文章,评审

doi：10.4155/fmc.09.25

authors： Page SM,Boss SR,Barker PD

更新日期：2009-06-01 00:00:00
Utilizing nature as a source of new probes for opioid pharmacology.
abstract：BACKGROUND:Traditional and current opioid pharmacology is fundamentally based on interactions between opioid receptors and compounds isolated from natural sources. Adverse effects associated with opioids have led to the search for compounds with diminished side effects. DISCUSSION:Recent discoveries of non-nitrogenous...

journal_title：Future medicinal chemistry

pub_type： 杂志文章,评审

doi：10.4155/fmc.09.22

authors： Lovell KM,Simpson DS,Cunningham CW,Prisinzano TE

更新日期：2009-05-01 00:00:00
Overview of computational methods employed in early-stage drug discovery.
abstract：BACKGROUND:The understanding of biomolecular interactions ultimately depends on knowledge about the structural and dynamic details of the interacting system. Rational structure-based drug design implements computational methodology in this rationale. DISCUSSION:Together with increasing throughput of structural biology...

journal_title：Future medicinal chemistry

pub_type： 杂志文章

doi：10.4155/fmc.09.7

authors： Skjevik AA,Teigen K,Martinez A

更新日期：2009-04-01 00:00:00

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